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Proteomic Analysis of Plasma Proteins after Low-Level Laser Therapy in Rats

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21720%2F19%3A00346786" target="_blank" >RIV/68407700:21720/19:00346786 - isvavai.cz</a>

  • Alternative codes found

    RIV/62157124:16170/19:43878408

  • Result on the web

    <a href="https://doi.org/10.33549/PHYSIOLRES.934377" target="_blank" >https://doi.org/10.33549/PHYSIOLRES.934377</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.33549/PHYSIOLRES.934377" target="_blank" >10.33549/PHYSIOLRES.934377</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Proteomic Analysis of Plasma Proteins after Low-Level Laser Therapy in Rats

  • Original language description

    The laser radiation absorbed by cells induces production of reactive oxygen species (ROS), followed by the development of oxidative stress. Proteins are major targets for ROS due to their abundance in biological systems. The aim of the present pilot study was to examine the effects of transcutaneous laser blood irradiation (TLBI), i.e., low-level laser therapy (LLLT) at 830 nm on plasma proteome in Wistar rats. Rats were irradiated in the heart area (i.e. coronary arteries) daily (i.e., for 9-day period), by commercially available GaAsAl diode laser (Maestro/CCM, Medicom Prague, Czech Republic, λ=830 nm, power density 450mW/cm2, daily dose 60,3 J/ cm2, irradiation time 134 sec). The comparison of blood plasma proteome from irradiated and non-irradiated rats was performed utilizing 2D electrophoresis followed by MALDI TOF/TOF mass spectrometry. LLLT led to a quantitative change in the acute phase proteins with antioxidant protection i.e., haptoglobin (log2 fold change (FC)=3.5), hemopexin (log2 FC=0.5), fibrinogen gamma (log2 FC=1.4), alpha-1-antitrypsin (log2 FC=-2.2), fetuin A (log2 FC=-0.6) and fetuin B (log2 FC=-2.3). In comparison to conventional biochemical methods, the changes in protein levels in blood plasma induced by LLLT offer a deeper insight into the oxidative stress response.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    21002 - Nano-processes (applications on nano-scale); (biomaterials to be 2.9)

Result continuities

  • Project

    <a href="/en/project/LO1605" target="_blank" >LO1605: University Centre for Energy Efficient Buildings – Sustainability Phase</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Physiological Research

  • ISSN

    0862-8408

  • e-ISSN

    1802-9973

  • Volume of the periodical

    68

  • Issue of the periodical within the volume

    Suppl. 4

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    6

  • Pages from-to

    "S399"-"S404"

  • UT code for WoS article

    000529413800005

  • EID of the result in the Scopus database

    2-s2.0-85081138479