Identification of Concealed and Manifest Long QT Syndrome Using a Novel T Wave Analysis Program

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21730%2F16%3A00303193" target="_blank" >RIV/68407700:21730/16:00303193 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1161/CIRCEP.115.003830" target="_blank" >https://doi.org/10.1161/CIRCEP.115.003830</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/CIRCEP.115.003830" target="_blank" >10.1161/CIRCEP.115.003830</a>

Result language

angličtina

Original language name

Identification of Concealed and Manifest Long QT Syndrome Using a Novel T Wave Analysis Program

Original language description

Background-Congenital long QT syndrome (LQTS) is characterized by QT prolongation. However, the QT interval itself is insufficient for diagnosis, unless the corrected QT interval is repeatedly >= 500 ms without an acquired explanation. Further, the majority of LQTS patients have a corrected QT interval below this threshold, and a significant minority has normal resting corrected QT interval values. Here, we aimed to develop and validate a novel, quantitative T wave morphological analysis program to differentiate LQTS patients from healthy controls. Methods and Results-We analyzed a genotyped cohort of 420 patients (22 +/- 16 years, 43% male) with either LQT1 (61%) or LQT2 (39%). ECG analysis was conducted using a novel, proprietary T wave analysis program that quantitates subtle changes in T wave morphology. The top 3 discriminating features in each ECG lead were determined and the lead with the best discrimination selected. Classification was performed using a linear discriminant classifier and validated on an untouched cohort. The top 3 features were Tpeak-Tend interval, T wave left slope, and T wave center of gravity x axis (last 25% of the T wave). Lead V6 had the best discrimination. It could distinguish 86.8% of LQTS patients from healthy controls. Moreover, it distinguished 83.33% of patients with concealed LQTS from controls, despite having essentially identical resting corrected QT interval values. Conclusions-T wave quantitative analysis on the 12-lead surface ECG provides an effective, novel tool to distinguish patients with either LQT1/LQT2 from healthy matched controls. It can provide guidance while mutation-specific genetic testing is in motion for family members.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Circulation: Arrhythmia and Electrophysiology

ISSN

1941-3149

e-ISSN

1941-3084

Volume of the periodical

9

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

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UT code for WoS article

000380610500006

EID of the result in the Scopus database

2-s2.0-84978835971