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Progress in biological and medical research in the deep underground: an update

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A90263%2F23%3A00371311" target="_blank" >RIV/68407700:90263/23:00371311 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.3389/fpubh.2023.1249742" target="_blank" >https://doi.org/10.3389/fpubh.2023.1249742</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3389/fpubh.2023.1249742" target="_blank" >10.3389/fpubh.2023.1249742</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Progress in biological and medical research in the deep underground: an update

  • Original language description

    As the growing population of individuals residing or working in deep underground spaces for prolonged periods, it has become imperative to understand the influence of factors in the deep underground environment (DUGE) on living systems. Heping Xie has conceptualized the concept of deep underground medicine to identify factors in the DUGE that can have either detrimental or beneficial effects on human health. Over the past few years, an increasing number of studies have explored the molecular mechanisms that underlie the biological impacts of factors in the DUGE on model organisms and humans. Here, we present a summary of the present landscape of biological and medical research conducted in deep underground laboratories and propose promising avenues for future investigations in this field. Most research demonstrates that low background radiation can trigger a stress response and affect the growth, organelles, oxidative stress, defense capacity, and metabolism of cells. Studies show that residing and/or working in the DUGE has detrimental effects on human health. Employees working in deep mines suffer from intense discomfort caused by high temperature and humidity, which increase with depth, and experience fatigue and sleep disturbance. The negative impacts of the DUGE on human health may be induced by changes in the metabolism of specific amino acids; however, the cellular pathways remain to be elucidated. Biological and medical research must continue in deep underground laboratories and mines to guarantee the safe probing of uncharted depths as humans utilize the deep underground space.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

  • Continuities

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    FRONTIERS IN PUBLIC HEALTH

  • ISSN

    2296-2565

  • e-ISSN

    2296-2565

  • Volume of the periodical

    11

  • Issue of the periodical within the volume

    1249742

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    9

  • Pages from-to

    1-9

  • UT code for WoS article

    001053624200001

  • EID of the result in the Scopus database

    2-s2.0-85168708204