Progress in biological and medical research in the deep underground: an update
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A90263%2F23%3A00371311" target="_blank" >RIV/68407700:90263/23:00371311 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.3389/fpubh.2023.1249742" target="_blank" >https://doi.org/10.3389/fpubh.2023.1249742</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fpubh.2023.1249742" target="_blank" >10.3389/fpubh.2023.1249742</a>
Alternative languages
Result language
angličtina
Original language name
Progress in biological and medical research in the deep underground: an update
Original language description
As the growing population of individuals residing or working in deep underground spaces for prolonged periods, it has become imperative to understand the influence of factors in the deep underground environment (DUGE) on living systems. Heping Xie has conceptualized the concept of deep underground medicine to identify factors in the DUGE that can have either detrimental or beneficial effects on human health. Over the past few years, an increasing number of studies have explored the molecular mechanisms that underlie the biological impacts of factors in the DUGE on model organisms and humans. Here, we present a summary of the present landscape of biological and medical research conducted in deep underground laboratories and propose promising avenues for future investigations in this field. Most research demonstrates that low background radiation can trigger a stress response and affect the growth, organelles, oxidative stress, defense capacity, and metabolism of cells. Studies show that residing and/or working in the DUGE has detrimental effects on human health. Employees working in deep mines suffer from intense discomfort caused by high temperature and humidity, which increase with depth, and experience fatigue and sleep disturbance. The negative impacts of the DUGE on human health may be induced by changes in the metabolism of specific amino acids; however, the cellular pathways remain to be elucidated. Biological and medical research must continue in deep underground laboratories and mines to guarantee the safe probing of uncharted depths as humans utilize the deep underground space.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
—
Continuities
—
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FRONTIERS IN PUBLIC HEALTH
ISSN
2296-2565
e-ISSN
2296-2565
Volume of the periodical
11
Issue of the periodical within the volume
1249742
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
1-9
UT code for WoS article
001053624200001
EID of the result in the Scopus database
2-s2.0-85168708204