Synthesis and properties of new adamantane-containing nitro compounds

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F05%3A63503741" target="_blank" >RIV/70883521:28110/05:63503741 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Synthesis and properties of new adamantane-containing nitro compounds
Original language description
Adamantane moiety introduced into the molecule of biologically active compound can significantly improve the properties of the resulting compounds. High lipophilic character of the adamantane cage increases the active compound permeability through the membranes and its availability in the target place. On the other hand presence of adamantane can overcome water solubility limitations of the original compounds by the complexation with cyclodextrines [1]. Formation of supramolecular complexes with properstability is necessary in order to combine of these two advantages. For this purpose the convenient adamantane-containing building blocks with modulated polarity are needed.We decided to prepare and examine properties of several anilines with 1-adamantylsubstituent bound by alkyl chain bearing hydroxy or keto group in addition. The first part of this investigation is presented.Adamantane-containing nitro compounds (see Fig.1) were prepared by nitration of corresponding ketones. These ke
Czech name
Syntéza a vlastnosti nových nitrosloučenin obsahujících 1-adamantylový zbytek
Czech description
Byly připraveny nové ketony nesoucí 1-adamantylový a fenylový substituent a byly zkoumány nitrace těchto ketonů. Byly popsány struktury nových nitrosloučenin jakožto produktů těchto nitrací.

Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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