A study of 2-substituted 3,1-benzoxazin-4-ones

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F12%3A43869044" target="_blank" >RIV/70883521:28110/12:43869044 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
A study of 2-substituted 3,1-benzoxazin-4-ones
Original language description
This paper describes our work concerning the preparation of novel benzoxazinones substituted with indole moiety or acyl in position 2. Their preparation is achieved by cyclodehydration of the appropriate N-acylanthranilic acids by means of acetic anhydride or thionyl chloride, which is consistent with the standard procedure. In addition, a new route to starting N-acylanthranilic acids has been established. Firstly, N-(?-ketoacyl)anthranilic acids were readily obtained from 4-hydroxyquinolin-2-ones by two-step oxidation including peracetic acid hydroxylation into the corresponding 3-hydroxyquinoline-2,4-diones and subsequent oxidative ring opening with periodic acid or sodium periodate. In the cases of the preparation of the mentioned indole derivatives, the appropriate transformations of ?-ketoacyl chain were carried out by known chemistry. As a part of our continued interest in the reactivity of various heterocyclic systems, we have studied reactions of title compounds with some nucle
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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