SYNTHESIS OF NOVEL AMPHUPHILIC HYALURONAN CONTAINING pi(.) (.) (.)pi CONJUGATED MOIETIES AS CARRIERS FOR DRUG DELIVERY

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F16%3A63517100" target="_blank" >RIV/70883521:28110/16:63517100 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
SYNTHESIS OF NOVEL AMPHUPHILIC HYALURONAN CONTAINING pi(.) (.) (.)pi CONJUGATED MOIETIES AS CARRIERS FOR DRUG DELIVERY
Original language description
Hyaluronan (HA) was chemically modified using various co-phenyl/ heteroaromatic alkanoic acids differing in the length of alkyl chains. HA was modified on hydroxyl moieties to keep carboxylic acid moieties unchanged. Prepared products were characterized using nuclear magnetic resonance (H-1, DOSY, HSQC), infrared spectroscopy and SEC-MALS. To determine whether the derivatives are suitable for drug delivery applications, the cell toxicity and critical aggregation concentrations were determined. The micelles of selected derivatives were loaded with aromatic hydrophobic drugs and the actual drug loading contents of these various micelles were compared.
Czech name
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Czech description
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Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
PROCEEDINGS OF THE 12TH INTERNATIONAL CONFERENCE ON POLYSACCHARIDES-GLYCOSCIENCE, 2016
ISBN
978-80-86238-59-3
ISSN
2336-6796
e-ISSN
neuvedeno
Number of pages
4
Pages from-to
63-66
Publisher name
Czech Chemical Society
Place of publication
Prague
Event location
Praha
Event date
Oct 19, 2016
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000388249900015

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