Bio-Artificial Polymeric System: PVA/CHI/AMP for Healthcare-Associated Infections Novel Treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F18%3A63521336" target="_blank" >RIV/70883521:28110/18:63521336 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/18:63521336
Result on the web
<a href="http://cps.utb.cz/images/aktuality/Sborn%C3%ADk_PLASTKO_2018.pdf" target="_blank" >http://cps.utb.cz/images/aktuality/Sborn%C3%ADk_PLASTKO_2018.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Bio-Artificial Polymeric System: PVA/CHI/AMP for Healthcare-Associated Infections Novel Treatment
Original language description
An interesting approach for facing healthcare-associated infections has been developed in the last decades. In this matter, a system based on poly (vinyl alcohol) (PVA), and chitosan (CHI) blended with an antibiotic (sodium ampicillin) (AMP) has been proposed as a new bio-artificial polymeric system (BAPS) with remarkable behavior due to the mechanical, physical, and biological properties. Despite of several studies of the antibacterial activity itself of the CHI, this property should be reinforced with an antibacterial substance. For this case, aqueous solutions of PVA at 1 % wt. were mixed with acid solution of CHI at 1 % wt. followed by adding AMP running from 0.3 % to 1.5 % wt. related to the total amount of the polymer. The obtained films were tested with common infectious strains associated with healthcare-associated infections; among them Staphylococcus aureus was included. The prepared BAPS revealed moderate antibacterial activity against the tested bacteria without adding a high antibiotic concentration. The findings of this study suggest the PVA-CHI systems under the presence of a widely used antibiotic as AMP may render effectiveness against bacterial strains and biofilm formation, being a promising view in the design of novel antimicrobial biomaterials potentially suitable for tissue engineering applications.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Plastko 2018
ISBN
978-80-7454-727-0
ISSN
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e-ISSN
neuvedeno
Number of pages
8
Pages from-to
155-162
Publisher name
Univerzita Tomáše Bati ve Zlíně
Place of publication
Zlín
Event location
Zlín
Event date
Apr 18, 2018
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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