Calcium phosphate incorporated bacterial cellulose-polyvinylpyrrolidone based hydrogel scaffold: Structural property and cell viability study for bone regeneration application

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F19%3A63523895" target="_blank" >RIV/70883521:28110/19:63523895 - isvavai.cz</a>

Alternative codes found

RIV/70883521:28610/19:63523895

Result on the web

<a href="https://www.mdpi.com/2073-4360/11/11/1821" target="_blank" >https://www.mdpi.com/2073-4360/11/11/1821</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/polym11111821" target="_blank" >10.3390/polym11111821</a>

Result language

angličtina

Original language name

Calcium phosphate incorporated bacterial cellulose-polyvinylpyrrolidone based hydrogel scaffold: Structural property and cell viability study for bone regeneration application

Original language description

This work focuses on the analysis of structural and functional properties of calcium phosphate (CaP) incorporated bacterial cellulose (BC)-polyvinylpyrrolidone (PVP) based hydrogel scaffolds referred to as &quot;CaP/BC-PVP&quot;. CaP is incorporated in the scaffolds in the form of hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) in different concentrations (beta-TCP: HA (w/w) = 20:80, 40:60, and 50:50). The scaffolds were characterized on the basis of porosity, thermal, biodegradation, mechanical, and cell viability/cytocompatibility properties. The structural properties of all the hydrogel scaffolds show significant porosity. The biodegradation of &quot;CaP/BC-PVP&quot; scaffold was evaluated following hydrolytic degradation. Weight loss profile, pH change, scanning electron microscopy (SEM), and Fourier Transform Infrared Spectroscopy (FTIR) study confirm the significant degradability of the scaffolds. It is observed that a 50:50_CaP/BC-PVP scaffold has the highest degree of degradation. On the other hand, the compressive strengths of CaP/BC-PVP hydrogel scaffolds are found between 0.21 to 0.31 MPa, which is comparable with the human trabecular bone. The cell viability study is performed with a human osteosarcoma Saos-2 cell line, where significant cell viability is observed in all the hydrogel scaffolds. This indicated their ability to facilitate cell growth and cell proliferation. Considering all these substantial properties, CaP/BC-PVP hydrogel scaffolds can be suggested for detailed investigation in the context of bone regeneration application.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

<a href="/en/project/LO1504" target="_blank" >LO1504: Centre of Polymer Systems Plus</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polymers

ISSN

2073-4360

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

24

Pages from-to

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UT code for WoS article

000503279200094

EID of the result in the Scopus database

2-s2.0-85075547311