A drug self-delivery system for cancer therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F19%3A63524236" target="_blank" >RIV/70883521:28110/19:63524236 - isvavai.cz</a>

Alternative codes found

RIV/70883521:28610/19:63524236

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

A drug self-delivery system for cancer therapy

Original language description

Cancer causes the second largest number of deaths globally. Poor water-solubility of most anti-cancer agents and the involute fabrication process of many carrier-based drug delivery systems heavily hinder their clinical application. Here we report an easy manufactured nanoformulation based on both irinotecan hydrochloride and curcumin, which can be effectively self-delivered without utilising any carriers. This nanoformulation shows near-mono size distributions, tuneable surface charges and good stability under various conditions. Their effective anti-cancer efficacy, improved passive targeting and alleviated side effects are confirmed by in vivo tests on nude mice. This promising drug self-delivery system not only did solve the problems related to these two molecules, but also show it is efficient for tumour regression and multiple therapeutic functions to achieve ameliorated cancer therapy, with promise for clinical translation.

Czech name

—

Czech description

—

Type

O - Miscellaneous

CEP classification

—

OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

<a href="/en/project/LO1504" target="_blank" >LO1504: Centre of Polymer Systems Plus</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů