Hyaluronan-based magneto-responsive hydrogel for biomedical applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F23%3A63571138" target="_blank" >RIV/70883521:28110/23:63571138 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/23:63571138
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Hyaluronan-based magneto-responsive hydrogel for biomedical applications
Original language description
A magneto-responsive hydrogel composed of hyaluronan-based (HA) matrix cross-linked via Schiff base formation, magnetic multicore particles (MCPs), and Al2O3 nanoparticles was elaborated. MCPs ensure the hydrogel heating (0.3 °C/minute) under exposure to an alternating magnetic field (AMF) approved for medicine. Rheological measurements confirmed shear-thinning behavior and fast recovery after high shear stress. Hydrogel was proven to be cytocompatible, with improved long-term stability at cell cultivation conditions. Viscoelastic properties of the hydrogel allowed extrusion-based 3D bioprinting with BALB/3T3 mouse fibroblasts forming self-supported, multi-layered, uniformly porous structure with homogeneous cell distribution and high cell viability. High heating efficiency, softness, biocompatibility, and 3D printability of magnetic HA hydrogel make it a multifunctional material suitable for AMF induced heating in biomedical applications such as magnetic hyperthermia, wireless thermal brain stimulation, thermally triggered drug delivery as well as for precise scaffold engineering and bioprinting.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů