Self-crosslinkable bacterial cellulose/chitosan/pectin injectable hydrogels: Design, characterization and preliminary biological performance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F25%3A63597139" target="_blank" >RIV/70883521:28110/25:63597139 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/25:63597139
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/app.57752" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/app.57752</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/app.57752" target="_blank" >10.1002/app.57752</a>
Alternative languages
Result language
angličtina
Original language name
Self-crosslinkable bacterial cellulose/chitosan/pectin injectable hydrogels: Design, characterization and preliminary biological performance
Original language description
In this study, multifunctional polysaccharide-based injectable hydrogels were developed using chitosan (CS) and dialdehyde bacterial cellulose (D-BC), interpenetrated with pectin (PT). The hydrogels exhibited rapid gelation, good water retention, and injectability under physiological conditions. Comprehensive characterization was performed to assess their chemical structure, internal morphology, thermal stability, and rheological behavior. The formation of dynamic Schiff base bonds between amine groups of CS and aldehyde groups of D-BC facilitated efficient crosslinking, resulting in rapid gelation and favorable swelling properties. The hydrogels also demonstrated shear-thinning behavior, contributing to their injectable and self-supporting characteristics. In vitro biocompatibility was evaluated over 21 days using gingival mesenchymal stem cells (GMSCs), with all formulations maintaining over 80% cell viability, confirming their cytocompatibility. Antibacterial assays revealed significant inhibition of Staphylococcus aureus, indicating promising antimicrobial performance. The 3D hydrogel networks provided a porous and stable structure suitable for cellular infiltration and tissue integration. Overall, this work presents a green, bio-based approach for fabricating injectable hydrogels with tunable physicochemical and biological properties, offering a potential platform for soft tissue repair applications, particularly in maxillofacial regeneration.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10620 - Other biological topics
Result continuities
Project
<a href="/en/project/TH71020005" target="_blank" >TH71020005: Bioactive injectable hydrogels for soft tissue regeneration after reconstructive maxillofacial surgeries</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Applied Polymer Science
ISSN
0021-8995
e-ISSN
1097-4628
Volume of the periodical
142
Issue of the periodical within the volume
45
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
nestránkováno
UT code for WoS article
001540648600001
EID of the result in the Scopus database
2-s2.0-105012153501