Effect of bariatric surgery on fatty liver disease in obese patients: A prospective one year follow-up study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28150%2F21%3A63535218" target="_blank" >RIV/70883521:28150/21:63535218 - isvavai.cz</a>

Alternative codes found

RIV/00843989:_____/22:E0109615 RIV/61988987:17110/21:A2302DEB

Result on the web

<a href="https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2731" target="_blank" >https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2731</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2021.021" target="_blank" >10.5507/bp.2021.021</a>

Result language

angličtina

Original language name

Effect of bariatric surgery on fatty liver disease in obese patients: A prospective one year follow-up study

Original language description

Background. Non-alcoholic fatty liver disease (NAFLD), often associated with obesity and metabolic syndrome, manifests itself as steatosis, hepatic fibrosis, cirrhosis, or even end-stage liver disease. NAFLD causes inflammation, insulin resistance and cardiovascular complications. The current study aimed to evaluate the beneficial effects of bariatric surgery on biochemical parameters of hepatic functions in obese patients by comparing them before and one-year after the surgery. Methods. A total of 72 morbidly obese patients underwent bariatric surgery between 2016 and 2018. The incidence of diabetes mellitus in this group was 29%, median body weight was 124.5 kg (109.0-140.0) and mean body mass index (BMI) was 44.38 +/- 6.770 kg/m(2). The used surgical procedures included gastric bypass, sleeve gastrectomy, laparoscopic gastric plication, and single anastomosis duodeno-ileal bypass-sleeve gastrectomy. Biochemical parameters including ALT/AST ratio (AAR), NAFLD fibrosis score (NFS), hepatic fibrosis index (FIB-4) and Fatty Liver Index (FLI) were evaluated in all patients at the time of surgery and one year after the intervention. Results. Significant improvement after the intervention was observed in 64 patients. A significant reduction in body weight (P&lt;0.0001), waist circumference (P&lt;0.0001), and body mass index (P&lt;0.0001) were observed. NAFLD liver fibrosis index changed significantly (P&lt;0.0001), suggesting a trend of improvement from advanced fibrosis towards stages 0-2. The FIB-4 fibrosis index indicated significant improvement (P=0.0136). Besides, a significant decline in hepatic steatosis (P&lt;0.0001) was observed after bariatric surgery as compared to the pre-surgery fatty liver conditions. Conclusion. Among the strategies to overcome NAFLD-associated impediments, bariatric surgery can be considered effective in reducing obesity and metabolic co-morbidities.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30212 - Surgery

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Volume of the periodical

neuveden

Issue of the periodical within the volume

neuvedeno

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

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UT code for WoS article

000731340500001

EID of the result in the Scopus database

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