STAR-SHAPED NANOPARTICLES BASED ON CARBOXY-TERMINATED POLYLACTIDE AND CHITOSAN FOR CONTROLLED RELEASE APPLICATIONS

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F15%3A43874036" target="_blank" >RIV/70883521:28610/15:43874036 - isvavai.cz</a>
Result on the web
<a href="http://www.nanocon.eu/files/proceedings/23/papers/4243.pdf" target="_blank" >http://www.nanocon.eu/files/proceedings/23/papers/4243.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
STAR-SHAPED NANOPARTICLES BASED ON CARBOXY-TERMINATED POLYLACTIDE AND CHITOSAN FOR CONTROLLED RELEASE APPLICATIONS
Original language description
In this work chitosan based nanoparticles were prepared and modified by a star-shaped carboxy-terminated polylactide (S-PLA) in order to reduce the doxorubicin burst effect in physiological solution. S-PLA was prepared by polycondensation reaction usingpentetic acid as a core molecule and methansulfonic acid as catalyst and linked to chitosan backbone through coupling reaction. Afterwards, chitosan-(S-PLA) modified nanoparticles loaded with doxorubicin were prepared by polyelectrolytes complexation method using dextran sulfate sodium salt as polyanion. Results show nanoparticles with diameter in the range 100-200 nm, spherical shape and zeta -potential between 27-35 mV. The presence of (S-PLA) side chain does not influence the encapsulation efficiencyof the drug but strongly reduce the initial burst effect compared with unmodified chitosan.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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