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The Optimization of Method for Preparing Microparticles

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F16%3A43875548" target="_blank" >RIV/70883521:28610/16:43875548 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The Optimization of Method for Preparing Microparticles

  • Original language description

    Alginate is a natural polysaccharide which is obtained from brown algae. Alginates are widely used in food industries. It is also used in pharmaceutical industries as a matrix for the entrapment or encapsulated drugs. Alginate particles can be produced in several ways. One of them is a spray-coagulation method. The particles produced by this method are porous. Calcium chloride solution is used as gelation agent in various concentrations. This study is focused on optimalization of method for preparing alginate particles mainly on their size and shape. Conditions that are changed are flow rate, air pressure, height of needle, concentration of alginate and CaCl2 solution. The shape and a surface of particles is identified from scanning electron microscopy (SEM). Their size is meassured by Mastersizer 3000 laser particle size analyzer. Results showed that changed conditions have an effect on physical properties of particles. The size of particles is decreased with decreasing flow rate, increasing pressure of air and also with more concentrated solution of calcium chloride.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

    CD - Macromolecular chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2016

  • Confidentiality

    C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.