The Optimization of Method for Preparing Microparticles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F16%3A43875548" target="_blank" >RIV/70883521:28610/16:43875548 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The Optimization of Method for Preparing Microparticles
Original language description
Alginate is a natural polysaccharide which is obtained from brown algae. Alginates are widely used in food industries. It is also used in pharmaceutical industries as a matrix for the entrapment or encapsulated drugs. Alginate particles can be produced in several ways. One of them is a spray-coagulation method. The particles produced by this method are porous. Calcium chloride solution is used as gelation agent in various concentrations. This study is focused on optimalization of method for preparing alginate particles mainly on their size and shape. Conditions that are changed are flow rate, air pressure, height of needle, concentration of alginate and CaCl2 solution. The shape and a surface of particles is identified from scanning electron microscopy (SEM). Their size is meassured by Mastersizer 3000 laser particle size analyzer. Results showed that changed conditions have an effect on physical properties of particles. The size of particles is decreased with decreasing flow rate, increasing pressure of air and also with more concentrated solution of calcium chloride.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.