Improvement of Temozolomide stability by loading in Chitosan-carboxy enriched Polylactide nanoparticles. In vitro evaluation.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F16%3A43875561" target="_blank" >RIV/70883521:28610/16:43875561 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Improvement of Temozolomide stability by loading in Chitosan-carboxy enriched Polylactide nanoparticles. In vitro evaluation.
Original language description
Temozolomide (TMZ) is a chemotherapeutic agent, which has demonstrated promising activity in treatment of some brain cancers and other solid tumors [1]. However, treatment is still a challenge due to the fast degradation of TMZ in the active form MTIC (5-Monomethyltriazenoimidazole-4-carboxamide) which is not able to reach the tumor site, in therapeutic concentration [2]. In this work, TMZ was physically entrapped into an amphiphilic carrier prepared by grafting carboxy- enriched polylactide to chitosan backbone. Obtained nanoparticles demonstrate diameter in the range 100-150 nm, high stability in physiological media and ability to accommodate up to 800 g of TMZ per mg of polymer. TMZ loaded in CS-PLA showed higher stability over time in comparison with the free drug, in particular in physiological solution at pH 7.4. In vitro cell tests demonstrate improvement of TMZ effectiveness when loaded into the carrier compared to the free drug counterparts.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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