Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F18%3A63521496" target="_blank" >RIV/70883521:28610/18:63521496 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles
Original language description
In the presented work the simultaneous use of ultrasound in tracking and smart release was investigated. Hybrid microparticles based on an iron core coated by a polysaccharide were prepared and loaded with doxorubicin. The possibility to trigger and control the release of the payload was demonstrated by application of ultrasound cycles at different power and time length. Results clearly indicate a direct correlation between the intensity of the release with the two parameters. A preliminary test using Sus Domestic liver demonstrates the possibility to visualize the faith of the microparticles after injection at the target site by a linear array ultrasound transducer. The dual function of the ultrasound; to visualize the position of the microparticles and afterwards trigger the release by changing the frequency was demonstrated offering a great perspective for a future biomedical application.
Czech name
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Czech description
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Type
D - Article in proceedings
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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