Effect of the configuration of poly(lactic acid) and content of poly(oxyethylene) blocks to the structure and functional properties of poly(lactic acid)-block-poly(oxirane)-based nanofibrous electrospun polyester–ether–urethanes used as potential drug-delivery system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F19%3A63523420" target="_blank" >RIV/70883521:28610/19:63523420 - isvavai.cz</a>
Alternative codes found
RIV/67985874:_____/19:00500688 RIV/00216208:11310/19:10403662
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.34331" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.34331</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jbm.b.34331" target="_blank" >10.1002/jbm.b.34331</a>
Alternative languages
Result language
angličtina
Original language name
Effect of the configuration of poly(lactic acid) and content of poly(oxyethylene) blocks to the structure and functional properties of poly(lactic acid)-block-poly(oxirane)-based nanofibrous electrospun polyester–ether–urethanes used as potential drug-delivery system
Original language description
Poly(lactic acid)-block-poly(oxirane)s (PLA-b-POE) of various compositions were prepared using a one-pot approach and then extended in a reaction with l-lysine diethyl ester diisocyanate, thereby forming polyester-ether-urethanes (PEU) with prolonged chains and units with increased degradability. The PEUs are processed by electrospinning to prepare degradable nanofibrous sheet materials with and without encapsulating the antibiotic Vancomycin (VAC). PLA block isomerism and POE blocks oligomeric content (1000 g/mol) affect the thermal properties, processability, nanofibrous sheet morphology, abiotic degradation, cytocompatibility, and encapsulated antibiotic release rate of prepared PEUs. Therefore, our findings provide an effective approach to tuning the functional properties of these advanced biocompatible materials.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biomedical Materials Research - Part B Applied Biomaterials
ISSN
1552-4973
e-ISSN
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Volume of the periodical
107
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
2378-2387
UT code for WoS article
000483702000018
EID of the result in the Scopus database
2-s2.0-85060786373