Tunable biomimetic hydrogels from silk fibroin and nanocellulose

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F20%3A63526459" target="_blank" >RIV/70883521:28610/20:63526459 - isvavai.cz</a>

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/acssuschemeng.9b05317" target="_blank" >https://pubs.acs.org/doi/10.1021/acssuschemeng.9b05317</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acssuschemeng.9b05317" target="_blank" >10.1021/acssuschemeng.9b05317</a>

Result language

angličtina

Original language name

Tunable biomimetic hydrogels from silk fibroin and nanocellulose

Original language description

Biomimetic hydrogels offer a new platform for hierarchical structure-controlled, tough, biocompatible, mechanically tunable, and printable gels for regenerative medicine. Herein, we report for the first time the detailed effects of various kinds of nanocellulose, namely, bacterial nanocellulose, cellulose nanofibers, and cellulose nanocrystals on the morphology, structure-property relationship, and 3D printability of the photochemically cross-linked regenerated silk fibroin (RSF)/nanocellulose composite hydrogels. The hierarchical structure of fabricated biomimetic hydrogels was both qualitatively and quantitatively investigated by scanning electron microscopy and small/ultrasmall-angle neutron scattering, whereas their mechanical properties were assessed using rheology, tensile, and indentation tests. The micropore size and interhydrophobic domain distance of fabricated hydrogels were tuned in the range of 1.8-9.2 μm and 4.5-17.7 nm, respectively. The composite hydrogels exhibit superior viscoelastic, compressive, and tensile mechanical properties compared to pristine RSF hydrogel, where the shear storage modulus, compression modulus, young&apos;s modulus, and tensile toughness were tuned in the range of 0.4-1.4, 1.3-3.6, 2.2-14.0 MPa, and 16.7-108.3 kJ/m3, respectively. Moreover, the obtained mechanical modulus of the composite hydrogels in terms of shear, tensile, and compression are comparable to articular cartilage (0.4-1.6 MPa), native femoral artery (∼9.0 MPa), and human medial meniscus (∼1.0 MPa) tissues, respectively, which demonstrate their potential for a wide range of tissue engineering applications. The whisker form of nanocellulose was observed to enhance the printability of composite hydrogels, whereas the fiber form enhanced the overall toughness of the composite hydrogels and promoted the fibroblast cell attachment, viability, and proliferation. The results presented here have implications for both fundamental understanding and potential applications of RSF/nanocellulose composite hydrogels for 3D-printed scaffolds and tissue engineering.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS Sustainable Chemistry &amp; Engineering

ISSN

2168-0485

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

2375-2389

UT code for WoS article

000514488600005

EID of the result in the Scopus database

2-s2.0-85080066720