Unexpected unique properties of conducting polymers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F23%3A63574198" target="_blank" >RIV/70883521:28610/23:63574198 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Unexpected unique properties of conducting polymers
Original language description
A large interest is currently growing in the field of combination of synthetic- and bio-polymers resulting in materials with unique properties. In case of conducting polymers, which are especially advantageous as cell-instructive materials, the colloidal particles are important as they are the onlyform of conducting polymers dispersible in aqueous environment. This characteristic makes them especially beneficial for preparation of composite biomaterials. The polyaniline colloidal particles prepared by chemical route are well known and frequently studied; however, we present a green,nature-friendly approach based on enzyme-based polymerization of one of the conducting polymers, polyaniline, which is synthetized via the oxidation of aniline with hydroperoxideactivated horseradish peroxidase and chitosan or poly(vinyl alcohol) as steric stabilizers. The particles prepared in this way prove, except for other properties, the interesting biological properties, mainly immunomodulatory effect. This is the first time the immunomodulatory effect of conducting polymer based colloidal particles was observed. Moreover, the colloidal particles were able to reduce oxidative stress and inhibit the production of reactive oxidation species by neutrophils and inflammatory cytokines by macrophages. The anti-inflammatory effect observed was related to their antioxidant activity, especially in the case of netrophils.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů