Thermoresponsive 2,3-dicarboxy hyaluronan/phenanthriplatin nanogels for the treatment of ovarian cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F24%3A63588998" target="_blank" >RIV/70883521:28610/24:63588998 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Thermoresponsive 2,3-dicarboxy hyaluronan/phenanthriplatin nanogels for the treatment of ovarian cancer

Original language description

Sequential regioselective oxidation of HA, which essentially triples the amount of carboxylic groups available for drug binding, can be used in tandem with other selective modifications to prepare thermoresponsive functional derivatives of HA. Prepared DCH-PhPt nanogel combines both thermoresponsivity and high drug carrier capacity into a highly promising drug delivery system exhibiting significant potential in cancer therapy, particularly for ovarian cancer and its cisplatin-resistant variants.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů