DIALDEHYDE POLYSACCHARIDE-POLYPYRROLE COPOLYMERS: GREEN SYNTHESIS AND PROMISING BIOMEDICAL PROPERTIES
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F25%3A63595418" target="_blank" >RIV/70883521:28610/25:63595418 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
DIALDEHYDE POLYSACCHARIDE-POLYPYRROLE COPOLYMERS: GREEN SYNTHESIS AND PROMISING BIOMEDICAL PROPERTIES
Original language description
The development of sustainable and biocompatible conductive materials is crucial foradvancements in bioelectronics and tissue engineering. Materials based on conductivepolymers such as polypyrrole (PPy) are particularly promising. However, they suffer fromseveral drawbacks, including rather harsh and problematic synthesis.This study presents a novel polysaccharide-based method for synthesizing conductive andhighly biocompatible materials using a newly discovered aldol condensation reaction betweendialdehyde polysaccharides (DAPs) and pyrrole. The reaction is spontaneous and runs inwater under mild conditions, eliminating the need for harsh oxidants or catalysts used inconventional PPy synthesis.This approach is highly versatile, allowing:(a) Efficient functionalization of various DAPs with pyrrole and its derivatives, e.g. tochange their surface properties or immobilize drugs;(b) Spontaneous in situ polymerization of pyrrole, facilitated by the uniquepolyaldehydic character of various DAPs based on cellulose, hyaluronate, or alginate;(c) Fabrication of highly conductive nanofibrous DAP/PPy composites with improveddurability and resilience due to covalent links between polysaccharide matrix and PPy.Spectroscopic techniques (FTIR, NMR), microscopy (SEM, TEM), and electrochemicalanalyses were employed to elucidate the reaction mechanism and properties of thesematerials.The study also investigates the bioactivity of these materials, revealing very low cytotoxicityand significant antioxidative, anti-inflammatory, and immunomodulatory effects, suggestingapplications in biosensors or advanced wound dressings.This work highlights the feasibility of creating high-performance, sustainable materials throughthe utilization of polysaccharide chemistry, offering a promising avenue for the development ofnext-generation conductive biomaterials.
Czech name
—
Czech description
—
Classification
Type
O - Miscellaneous
CEP classification
—
OECD FORD branch
20901 - Industrial biotechnology
Result continuities
Project
<a href="/en/project/GA24-11534S" target="_blank" >GA24-11534S: Conductive (bio)polymer composites with covalently anchored polypyrrole for biomedical applications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů