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The synthetic N-terminal peptide of human lactorerrin hLF(1-11) is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F04%3A00005621" target="_blank" >RIV/75010330:_____/04:00005621 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The synthetic N-terminal peptide of human lactorerrin hLF(1-11) is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii

  • Original language description

    The lactoferrin-derrived peptide hLF(1-11), but not its control peptide, was fighly effective against five multidrug-resistant Acinetobacter baumannii strains in vitro (3 to 4 log reduction) and against four of these strains in anexperimental infection in mice (2 to 3 log reduction). Therefore, this peptide is a promising candidate as a novel agent against infections with multidrug-resistant A. baumannii.

  • Czech name

    Syntetický N-terminální peptid lidského laktoferinu hLF (1-11) je vysoce účinný proti experimentální infekci vyvolané multirezistentním Acinetobacter baumannii

  • Czech description

    Peptid hLF(1-11) odvozený od laktoferrinu, ale nikoliv peptid kontrolní, byl vysoce účinný proti pěti multirezistentním kmenům Acinetobacter baumannii in vitro (snížení o 3 až 4 log) a proti čtyřem z těchto kmenův experimentální infekci u myší (snížení o2 až 3 log), tudíž je tento peptid slibným kandidátem jako nové agens proti infekcím multirezistentním A. baumannii.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA310%2F01%2F1540" target="_blank" >GA310/01/1540: Evolution of multiresistance in Acinetobacter baumannii: the relationship betwen clonality and aminoglycoside resistance</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Antimicrobial Agents and Chemotherapy

  • ISSN

    0066-4804

  • e-ISSN

  • Volume of the periodical

    48

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    3

  • Pages from-to

    4919-4921

  • UT code for WoS article

  • EID of the result in the Scopus database