Chicken immunoglobulins for prophylaxis: effect of inhaled antibodies on inflammatory parameters in rat airways

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F15%3A00010772" target="_blank" >RIV/75010330:_____/15:00010772 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/15:10311957 RIV/00216208:11120/15:43909036 RIV/00023001:_____/15:00059357

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S1214021X14000684" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1214021X14000684</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jab.2014.04.003" target="_blank" >10.1016/j.jab.2014.04.003</a>

Result language

angličtina

Original language name

Chicken immunoglobulins for prophylaxis: effect of inhaled antibodies on inflammatory parameters in rat airways

Original language description

The prophylaxis against microbial airway infections of cystic fibrosis (CF) patients is an emerging application of chicken yolk antibody (IgY), however, no data on the effect of inhaled IgY have been published yet. Rats were daily (for 28 days) exposed to an aerosol of IgY, ovalbumin (OVA), Fab fragment of IgY, or PBS and their serum, bronchoalveolar lavage (BAL) and lung tissue were examined for inflammation signs. There were no marked changes in lung parenchyma, except for an elevated number of alveolar macrophages in the OVA-exposed group. While the administration of OVA or IgY aerosols slightly increased levels of cytokine TNF-alpha and GRO/KC in BAL fluid, a marked elevation of GM-CSF in serum was observed after the OVA inhalation. The administration of Fab induced expression of IL-1beta &gt; IL-18 in serum, in contrast no effect exerted by IgY. Our results suggest that the aerosolized IgY did not cause any deleterious effects in rat lungs.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

19-22

UT code for WoS article

000350670600002

EID of the result in the Scopus database

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