Analysis of Bordetella pertussis clinical isolates circulating in European countries during the period 1998–2012
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F15%3A00010820" target="_blank" >RIV/75010330:_____/15:00010820 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs10096-014-2297-2" target="_blank" >http://link.springer.com/article/10.1007%2Fs10096-014-2297-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10096-014-2297-2" target="_blank" >10.1007/s10096-014-2297-2</a>
Alternative languages
Result language
angličtina
Original language name
Analysis of Bordetella pertussis clinical isolates circulating in European countries during the period 1998–2012
Original language description
Despite more than 50 years of vaccination, pertussis is still an endemic disease, with regular epidemic outbreaks. With the exception of Poland, European countries have replaced whole-cell vaccines (WCVs) by acellular vaccines (ACVs) in the 1990s. Worldwide, antigenic divergence in vaccine antigens has been found between vaccine strains and circulating strains. In this work, 466 Bordetella pertussis isolates collected in the period 1998–2012 from 13 European countries were characterised by multi-locus antigen sequence typing (MAST) of the pertussis toxin promoter (ptxP) and of the genes coding for proteins used in the ACVs: pertussis toxin (Ptx), pertactin (Prn), type 2 fimbriae (Fim2) and type 3 fimbriae (Fim3). Isolates were further characterised by fimbrial serotyping, multi-locus variable-number tandem repeat analysis (MLVA) and pulsed-field gel electrophoresis (PFGE). The results showed a very similar B. pertussis population for 12 countries using ACVs, while Poland, which uses a WCV, was quite distinct, suggesting that ACVs and WCVs select for different B. pertussis populations. This study forms a baseline for future studies on the effect of vaccination programmes on B. pertussis populations.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14058" target="_blank" >NT14058: Study and comparison of the Bordetella pertussis strains isolated during the period 1964-2015 by molecular biological methods and applications of the results as the basis for the draft update of vaccination strategies in the Czech Republic</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Clinical Microbiology and Infectious Diseases
ISSN
0934-9723
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
821-830
UT code for WoS article
000351513900024
EID of the result in the Scopus database
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