Blood-based oxidative stress markers and cognitive performance in early old age: the HAPIEE Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F16%3A00011567" target="_blank" >RIV/75010330:_____/16:00011567 - isvavai.cz</a>
Result on the web
<a href="https://www.karger.com/Article/FullText/450702" target="_blank" >https://www.karger.com/Article/FullText/450702</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000450702" target="_blank" >10.1159/000450702</a>
Alternative languages
Result language
angličtina
Original language name
Blood-based oxidative stress markers and cognitive performance in early old age: the HAPIEE Study
Original language description
Background/Aims: Oxidative stress is involved in Alzheimer disease pathology, but its impact on cognitive function in community-dwelling older adults remains unknown. We estimated associations between serum oxidative stress markers and cognitive function in early old age. Methods: Subjects aged 45-69 years recruited in urban centers in Central and Eastern Europe had memory, verbal fluency, and processing speed assessed at baseline (2002-2005) and 3 years later. Derivatives of reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and total thiol levels (TTLs) were measured at baseline in a subsample. Linear regression was used to estimate associations of biomarkers with cognitive test scores cross-sectionally (n = 4,304) and prospectively (n = 2,882). Results: Increased d-ROM levels were inversely associated with global cognition and verbal fluency cross-sectionally and in prospective analysis; observed effects corresponded to 3-4 years' higher age. TTL was inconsistently associated with memory. BAP was not related to cognitive function. Conclusion: This study found modest evidence for a relationship between serum d-ROMs and cognitive function in a population sample of older adults.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FQ - Public health system, social medicine
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Dementia and Geriatric Cognitive Disorders
ISSN
1420-8008
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
5-6
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
297-309
UT code for WoS article
000390096200005
EID of the result in the Scopus database
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