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Blood-based oxidative stress markers and cognitive performance in early old age: the HAPIEE Study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F16%3A00011567" target="_blank" >RIV/75010330:_____/16:00011567 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.karger.com/Article/FullText/450702" target="_blank" >https://www.karger.com/Article/FullText/450702</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1159/000450702" target="_blank" >10.1159/000450702</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Blood-based oxidative stress markers and cognitive performance in early old age: the HAPIEE Study

  • Original language description

    Background/Aims: Oxidative stress is involved in Alzheimer disease pathology, but its impact on cognitive function in community-dwelling older adults remains unknown. We estimated associations between serum oxidative stress markers and cognitive function in early old age. Methods: Subjects aged 45-69 years recruited in urban centers in Central and Eastern Europe had memory, verbal fluency, and processing speed assessed at baseline (2002-2005) and 3 years later. Derivatives of reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and total thiol levels (TTLs) were measured at baseline in a subsample. Linear regression was used to estimate associations of biomarkers with cognitive test scores cross-sectionally (n = 4,304) and prospectively (n = 2,882). Results: Increased d-ROM levels were inversely associated with global cognition and verbal fluency cross-sectionally and in prospective analysis; observed effects corresponded to 3-4 years' higher age. TTL was inconsistently associated with memory. BAP was not related to cognitive function. Conclusion: This study found modest evidence for a relationship between serum d-ROMs and cognitive function in a population sample of older adults.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FQ - Public health system, social medicine

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Dementia and Geriatric Cognitive Disorders

  • ISSN

    1420-8008

  • e-ISSN

  • Volume of the periodical

    42

  • Issue of the periodical within the volume

    5-6

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    13

  • Pages from-to

    297-309

  • UT code for WoS article

    000390096200005

  • EID of the result in the Scopus database