Plasma endoxifen and 4-hydroxytamoxifen levels in CYP2D6(C100T) carrying breast cancer patients and association with serum cholesterol
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F19%3A00012661" target="_blank" >RIV/75010330:_____/19:00012661 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0041008X19302212?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0041008X19302212?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.taap.2019.114619" target="_blank" >10.1016/j.taap.2019.114619</a>
Alternative languages
Result language
angličtina
Original language name
Plasma endoxifen and 4-hydroxytamoxifen levels in CYP2D6(C100T) carrying breast cancer patients and association with serum cholesterol
Original language description
Breast cancer patients with high cholesterol biosynthesis signature had poorer therapeutic outcome. Cytothrome P450 (CYP) 2D6 is crucial in the oxidation of tamoxifen to generate active metabolites, 4-hydroxytamoxifen and endoxifen. CYP2D6 variants with ClOOT substitution encode null or poor functional proteins. This study aims to examine the association of ClOOT genotypes and serum lipid levels with plasma drug levels in patients. Plasma tamoxifen concentration was positively associated with serum triglyceride concentration, adjusting for age and ClOOT genotype. Overweight (body mass index > 24.0) patients with high serum cholesterol (>= 200 mg/dL) had increased risks of ineffective endoxifen levels (< 5.97 ng/mL). Compared to the low-cholesterol group, the high-cholesterol group had a lower 4-hydroxytamoxifen or endoxifen level in T/T carriers. In T/T carriers, the high-cholesterol group had an increased risk of an ineffective endoxifen level. Metastasis, hot flash/flushing, and high alanine transaminase did not relate to plasma 4-hydrmrytarnoxifen or endoxifen levels. Results indicate that ClOOT and high serum cholesterol are risk factors of ineffective endoxifen levels in Taiwanese breast cancer patients. These findings warrant further studies of a large hypercholesterolemic population to examine the outcome of increased doses of tamoxifen.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/NV17-28470A" target="_blank" >NV17-28470A: Importance of oxysterol signaling for endocrine therapy of breast carcinoma</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology and Applied Pharmacology
ISSN
0041-008X
e-ISSN
1096-0333
Volume of the periodical
378
Issue of the periodical within the volume
September
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
114619
UT code for WoS article
000477917100013
EID of the result in the Scopus database
2-s2.0-85067983507