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Plasma endoxifen and 4-hydroxytamoxifen levels in CYP2D6(C100T) carrying breast cancer patients and association with serum cholesterol

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F19%3A00012661" target="_blank" >RIV/75010330:_____/19:00012661 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S0041008X19302212?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0041008X19302212?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.taap.2019.114619" target="_blank" >10.1016/j.taap.2019.114619</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Plasma endoxifen and 4-hydroxytamoxifen levels in CYP2D6(C100T) carrying breast cancer patients and association with serum cholesterol

  • Original language description

    Breast cancer patients with high cholesterol biosynthesis signature had poorer therapeutic outcome. Cytothrome P450 (CYP) 2D6 is crucial in the oxidation of tamoxifen to generate active metabolites, 4-hydroxytamoxifen and endoxifen. CYP2D6 variants with ClOOT substitution encode null or poor functional proteins. This study aims to examine the association of ClOOT genotypes and serum lipid levels with plasma drug levels in patients. Plasma tamoxifen concentration was positively associated with serum triglyceride concentration, adjusting for age and ClOOT genotype. Overweight (body mass index > 24.0) patients with high serum cholesterol (>= 200 mg/dL) had increased risks of ineffective endoxifen levels (< 5.97 ng/mL). Compared to the low-cholesterol group, the high-cholesterol group had a lower 4-hydroxytamoxifen or endoxifen level in T/T carriers. In T/T carriers, the high-cholesterol group had an increased risk of an ineffective endoxifen level. Metastasis, hot flash/flushing, and high alanine transaminase did not relate to plasma 4-hydrmrytarnoxifen or endoxifen levels. Results indicate that ClOOT and high serum cholesterol are risk factors of ineffective endoxifen levels in Taiwanese breast cancer patients. These findings warrant further studies of a large hypercholesterolemic population to examine the outcome of increased doses of tamoxifen.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/NV17-28470A" target="_blank" >NV17-28470A: Importance of oxysterol signaling for endocrine therapy of breast carcinoma</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Toxicology and Applied Pharmacology

  • ISSN

    0041-008X

  • e-ISSN

    1096-0333

  • Volume of the periodical

    378

  • Issue of the periodical within the volume

    September

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    114619

  • UT code for WoS article

    000477917100013

  • EID of the result in the Scopus database

    2-s2.0-85067983507