Exposure to mixed phthalates in Czech preschool and school children
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F19%3A00012703" target="_blank" >RIV/75010330:_____/19:00012703 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/19:43918388
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00244-019-00645-6" target="_blank" >https://link.springer.com/article/10.1007%2Fs00244-019-00645-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00244-019-00645-6" target="_blank" >10.1007/s00244-019-00645-6</a>
Alternative languages
Result language
angličtina
Original language name
Exposure to mixed phthalates in Czech preschool and school children
Original language description
Knowledge of population exposure to phthalates based on the urinary metabolite levels is of the highest importance for health risk assessment. Such data are scarce in the Czech population. In the study conducted in 2016, six urinary phthalate metabolites were analysed in a total of 370 first morning urine samples of healthy children aged 5 and 9 years, namely mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), mono(2-ethyl-5-oxohexyl) phthalate (5oxo-MEHP), mono-benzyl phthalate (MBzP), mono-iso-butyl phthalate (MiBP), and mono-n-butyl phthalate (MnBP). The two latter mono-butyl phthalate isoforms dominated among all samples with geometric means of 63.0 mu g/L (MnBP) and 44.1 mu g/L (MiBP), followed by 5OH-MEHP (20.6 mu g/L), 5oxo-MEHP (12.9 mu g/L), MBzP (3.65 mu g/L), and MEHP (2.31 mu g/L). Daily intake (DI) of the parent phthalates was estimated using the creatinine-based model. The highest DI values were found for di-n-butyl phthalate (DnBP) (median 2.5 mu g/kg bw/day; 95th percentile 7.8 mu g/kg bw/day) and di-2-ethylhexyl phthalate (DEHP) (median 2.3 mu g/kg bw/day; 95th percentile 8.9 mu g/kg bw/day) in 5-year-old children. The tolerable daily intake (TDI) set by the European Food Safety Authority (EFSA) was exceeded in case of DnBP (in 1% of 9-year-olds and in 3% of 5-year-olds). Exposure risk was assessed based on hazard quotients calculation and cumulative approach for similar health effect. The combined exposure to four phthalates expressed by hazard index (HI) for reprotoxicity revealed exceeding of HI threshold in 14% of 5-year-olds and in 9% of 9-year-olds. These findings strongly support the need to reduce the burden of children by phthalates.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archives of Environmental Contamination and Toxicology
ISSN
0090-4341
e-ISSN
1432-0703
Volume of the periodical
77
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
471-479
UT code for WoS article
000490600200001
EID of the result in the Scopus database
2-s2.0-85071517628