Toxicity of food contact paper evaluated by combined biological and chemical methods
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F19%3A00012819" target="_blank" >RIV/75010330:_____/19:00012819 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/19:43917909 RIV/00216208:11310/19:10395837
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0887233318307847?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0887233318307847?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tiv.2019.04.001" target="_blank" >10.1016/j.tiv.2019.04.001</a>
Alternative languages
Result language
angličtina
Original language name
Toxicity of food contact paper evaluated by combined biological and chemical methods
Original language description
The study was focused on assessment of potential health risks of paper-based food contact materials (FCMs) in a step-wise approach using three toxicological bioassays in vitro and chemical analyses of migrating contaminants. 3T3 NRU cytotoxicity test showed high sensitivity to detect basal toxicity of FCMs extracts and served as a firstline test for selection of samples for further testing. The reconstructed human intestine model EpiIntestinal showed more realistic tissue response than cell culture monolayer and higher resistance despite prolonged exposure to the selected 6 samples, i.e. negligible decrease of viability and intestinal penetration, nevertheless an increase of IL-8 after exposure to black printed sample extract. Yeast based assays identified weak agonistic/antagonostic activity to human androgen receptor of the black printed sample. In accordance with the biological effects, the targeted LC and GC analytical methods confirmed the presence of high amounts of phthalates, photoinitiators and PAHs that could justify the hazard of the black printed sample. Heavily printed uncoated FCMs are recognized not to be suitable for direct contact with food. The selected bioassays and chemical analyses might be useful tools to detect targeted biological effects of xenobiotics suspected to contribute to human exposure from food.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
<a href="/en/project/EF16_019%2F000860" target="_blank" >EF16_019/000860: International competitiveness of NIPH in research, development and education in alternative toxicological methods.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology in Vitro
ISSN
0887-2333
e-ISSN
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Volume of the periodical
59
Issue of the periodical within the volume
September
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
26-34
UT code for WoS article
000477790900003
EID of the result in the Scopus database
2-s2.0-85063760964