Proposal of new health risk assessment method for deficient essential elements in drinking water-case study of the Slovak Republic
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F20%3A00013263" target="_blank" >RIV/75010330:_____/20:00013263 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1660-4601/17/16/5915" target="_blank" >https://www.mdpi.com/1660-4601/17/16/5915</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijerph17165915" target="_blank" >10.3390/ijerph17165915</a>
Alternative languages
Result language
angličtina
Original language name
Proposal of new health risk assessment method for deficient essential elements in drinking water-case study of the Slovak Republic
Original language description
The US EPA health risk assessment method is currently widely used to assess human health risks for many environmental constituents. It is used for risk assessment from the exposure to various contaminants exceeding tolerable or safe reference doses, determined e.g., for drinking water, soil, air and food. It accepts widely that excess contents of non-essential elements (e.g., As, Pb or Sb) in environmental compartments represent a general risk to human health. However, contrary to toxic trace elements, deficient contents of essential (biogenic) elements e.g., F, I, Se, Zn, Fe, Ca or Mg may represent even higher health risk. Therefore, we propose to extend the human health risk assessment by calculating the health risk for deficient content and intake of essential elements, and to introduce the terms Average Daily Missing Dose (ADMD), Average Daily Required Dose (ADRD) and Average Daily Accepted Dose (ADAD). We propose the following equation to calculate the Hazard Quotient (HQ) of health risk from deficient elements: HQ(d)= ADRD/ADAD. At present, there are no reference concentrations or doses of essential elements in each environmental compartment in world databases (Integrated Risk Information System IRIS, The Risk Assessment Information System RAIS). ADRD and ADMD can be derived from different regulatory standards or guidelines (if they exist) or calculated from actual regional data on the state of population health and content of essential elements in the environment, e.g., in groundwater or soil. This methodology was elaborated and tested on inhabitants of the Slovak Republic supplied with soft drinking water with an average Mg content of 5.66 mg center dot L-1. The calculated ADMD of Mg for these inhabitants is 0.314 mg center dot kg(-1)center dot day(-1)and HQ(d)is equal to 2.94, indicating medium risk of chronic diseases. This method extending traditional health risk assessment is the first attempt to quantify deficient content of essential elements in drinking water. It still has some limitations but also has potential to be further developed and refined through its testing in other countries.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Environmental Research and Public Health
ISSN
1660-4601
e-ISSN
1660-4601
Volume of the periodical
17
Issue of the periodical within the volume
16
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
5915
UT code for WoS article
000565097100001
EID of the result in the Scopus database
2-s2.0-85089620998