Qualitative and quantitative analysis of certain aspects of the cytotoxic and genotoxic hazard of hospital wastewaters by using a range of in vitro assays
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F21%3A00013511" target="_blank" >RIV/75010330:_____/21:00013511 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41330/21:88240
Result on the web
<a href="https://journals.sagepub.com/doi/10.1177/02611929211004956" target="_blank" >https://journals.sagepub.com/doi/10.1177/02611929211004956</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/02611929211004956" target="_blank" >10.1177/02611929211004956</a>
Alternative languages
Result language
angličtina
Original language name
Qualitative and quantitative analysis of certain aspects of the cytotoxic and genotoxic hazard of hospital wastewaters by using a range of in vitro assays
Original language description
Health care facilities and hospitals generate significant amounts of wastewater which are released into the sewage system, either after a preliminary treatment or without any further treatment. Hospital wastewater may contain large amounts of hazardous chemicals and pharmaceuticals, some of which cannot be eliminated entirely by wastewater treatment plants. Moreover, hospital effluents may be loaded with a plethora of pathogenic microorganisms or other microbiota and microbiome residues. The need to monitor hospital effluents for their genotoxic hazard is of high importance, as detailed information is scarce. DNA-based information can be acquired directly from samples through the application of various molecular methods, while cell-based biomonitoring assays can provide important information about impaired cellular pathways or mechanisms of toxicity without prior knowledge of the identity of each toxicant. In our study, we evaluated samples of chlorinated hospital wastewater discharged into the sewage system after this disinfection process. The assessment of cytotoxicity, genotoxicity and mutagenicity of the hospital effluents was performed in vitro by using a broad battery of biomonitoring assays that are relevant for human health effects. All the tested hospital wastewater samples could be classified as potentially genotoxic, and it is concluded that the microbiota present in hospital wastewater might contribute to this genotoxic potential.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30108 - Toxicology
Result continuities
Project
<a href="/en/project/EF16_019%2F000860" target="_blank" >EF16_019/000860: International competitiveness of NIPH in research, development and education in alternative toxicological methods.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Alternatives to Laboratory Animals: ATLA
ISSN
0261-1929
e-ISSN
2632-3559
Volume of the periodical
49
Issue of the periodical within the volume
1-2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
33-48
UT code for WoS article
000659446000011
EID of the result in the Scopus database
2-s2.0-85107902610