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Qualitative and quantitative analysis of certain aspects of the cytotoxic and genotoxic hazard of hospital wastewaters by using a range of in vitro assays

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F21%3A00013511" target="_blank" >RIV/75010330:_____/21:00013511 - isvavai.cz</a>

  • Alternative codes found

    RIV/60460709:41330/21:88240

  • Result on the web

    <a href="https://journals.sagepub.com/doi/10.1177/02611929211004956" target="_blank" >https://journals.sagepub.com/doi/10.1177/02611929211004956</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1177/02611929211004956" target="_blank" >10.1177/02611929211004956</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Qualitative and quantitative analysis of certain aspects of the cytotoxic and genotoxic hazard of hospital wastewaters by using a range of in vitro assays

  • Original language description

    Health care facilities and hospitals generate significant amounts of wastewater which are released into the sewage system, either after a preliminary treatment or without any further treatment. Hospital wastewater may contain large amounts of hazardous chemicals and pharmaceuticals, some of which cannot be eliminated entirely by wastewater treatment plants. Moreover, hospital effluents may be loaded with a plethora of pathogenic microorganisms or other microbiota and microbiome residues. The need to monitor hospital effluents for their genotoxic hazard is of high importance, as detailed information is scarce. DNA-based information can be acquired directly from samples through the application of various molecular methods, while cell-based biomonitoring assays can provide important information about impaired cellular pathways or mechanisms of toxicity without prior knowledge of the identity of each toxicant. In our study, we evaluated samples of chlorinated hospital wastewater discharged into the sewage system after this disinfection process. The assessment of cytotoxicity, genotoxicity and mutagenicity of the hospital effluents was performed in vitro by using a broad battery of biomonitoring assays that are relevant for human health effects. All the tested hospital wastewater samples could be classified as potentially genotoxic, and it is concluded that the microbiota present in hospital wastewater might contribute to this genotoxic potential.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30108 - Toxicology

Result continuities

  • Project

    <a href="/en/project/EF16_019%2F000860" target="_blank" >EF16_019/000860: International competitiveness of NIPH in research, development and education in alternative toxicological methods.</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Alternatives to Laboratory Animals: ATLA

  • ISSN

    0261-1929

  • e-ISSN

    2632-3559

  • Volume of the periodical

    49

  • Issue of the periodical within the volume

    1-2

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    16

  • Pages from-to

    33-48

  • UT code for WoS article

    000659446000011

  • EID of the result in the Scopus database

    2-s2.0-85107902610