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Steroid ligands, the forgotten triggers of nuclear receptor action; implications for acquired resistance to endocrine therapy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F21%3A00013523" target="_blank" >RIV/75010330:_____/21:00013523 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11140/21:10426631

  • Result on the web

    <a href="https://clincancerres.aacrjournals.org/content/27/14/3980" target="_blank" >https://clincancerres.aacrjournals.org/content/27/14/3980</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1158/1078-0432.CCR-20-4135" target="_blank" >10.1158/1078-0432.CCR-20-4135</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Steroid ligands, the forgotten triggers of nuclear receptor action; implications for acquired resistance to endocrine therapy

  • Original language description

    Purpose: There is strong epidemiologic evidence indicating that estrogens may not be the sole steroid drivers of breast cancer. We hypothesize that abundant adrenal androgenic steroid precursors, acting via the androgen receptor (AR), promote an endocrine-resistant breast cancer phenotype. Experimental Design: AR was evaluated in a primary breast cancer tissue microarray (n = 844). Androstenedione (4AD) levels were evaluated in serum samples (n = 42) from hormone receptor-positive, postmenopausal breast cancer. Levels of androgens, progesterone, and estradiol were quantified using LC/MS-MS in serum from age- and grade-matched recurrent and nonrecurrent patients (n = 6) before and after aromatase inhibitor (AI) therapy (>12 months). AR and estrogen receptor (ER) signaling pathway activities were analyzed in two independent AI-treated cohorts. Results: AR protein expression was associated with favorable progression-free survival in the total population (Wilcoxon, P < 0.001). Pretherapy serum samples from breast cancer patients showed decreasing levels of 4AD with age only in the nonrecurrent group (P < 0.05). LC/MS-MS analysis of an AI-sensitive and AI-resistant cohort demonstrated the ability to detect altered levels of steroids in serum of patients before and after AI therapy. Transcriptional analysis showed an increased ratio of AR:ER signaling pathway activities in patients failing AI therapy (t test P < 0.05); furthermore, 4AD mediated gene changes associated with acquired AI resistance. Conclusions: This study highlights the importance of examining the therapeutic consequences of the steroid microenvironment and demonstrable receptor activation using indicative gene expression signatures.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/NV17-28470A" target="_blank" >NV17-28470A: Importance of oxysterol signaling for endocrine therapy of breast carcinoma</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Cancer Research

  • ISSN

    1078-0432

  • e-ISSN

    1557-3265

  • Volume of the periodical

    27

  • Issue of the periodical within the volume

    14

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    3980-3989

  • UT code for WoS article

    000674703200022

  • EID of the result in the Scopus database

    2-s2.0-85110067421