Age-specific associations between underlying health conditions and hospitalisation, death and in-hospital death among confirmed COVID-19 cases: a multi-country study based on surveillance data, June to December 2020
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F22%3A00014134" target="_blank" >RIV/75010330:_____/22:00014134 - isvavai.cz</a>
Result on the web
<a href="https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2022.27.35.2100883" target="_blank" >https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2022.27.35.2100883</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2807/1560-7917.ES.2022.27.35.2100883" target="_blank" >10.2807/1560-7917.ES.2022.27.35.2100883</a>
Alternative languages
Result language
angličtina
Original language name
Age-specific associations between underlying health conditions and hospitalisation, death and in-hospital death among confirmed COVID-19 cases: a multi-country study based on surveillance data, June to December 2020
Original language description
Background: Underlying conditions are risk factors for severe COVID-19 outcomes but evidence is limited about how risks differ with age. Aim: We sought to estimate age-specific associations between underlying conditions and hospitalisation, death and in-hospital death among COVID-19 cases. Methods: We analysed case-based COVID-19 data submitted to The European Surveillance System between 2 June and 13 December 2020 by nine European countries. Eleven underlying conditions among cases with only one condition and the number of underlying conditions among multimorbid cases were used as exposures. Adjusted odds ratios (aOR) were estimated using 39 different age-adjusted and age-interaction multivariable logistic regression models, with marginal means from the latter used to estimate probabilities of severe outcome for each condition-age group combination. Results: Cancer, cardiac disorder, diabetes, immunodeficiency, kidney, liver and lung disease, neurological disorders and obesity were associated with elevated risk (aOR: 1.5-5.6) of hospitalisation and death, after controlling for age, sex, reporting period and country. As age increased, age-specific aOR were lower and predicted probabilities higher. However, for some conditions, predicted probabilities were at least as high in younger individuals with the condition as in older cases without it. In multimorbid patients, the aOR for severe disease increased with number of conditions for outcomes and in all age groups. Conclusion: While supporting age-based vaccine roll-out, our findings could inform a more nuanced, age- and condition-specific approach to vaccine prioritisation. This is relevant as countries consider vaccination of younger people, boosters and dosing intervals in response to vaccine escape variants.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Euro Surveillance
ISSN
1025-496X
e-ISSN
1560-7917
Volume of the periodical
27
Issue of the periodical within the volume
35
Country of publishing house
SE - SWEDEN
Number of pages
14
Pages from-to
2100883
UT code for WoS article
000890390100004
EID of the result in the Scopus database
2-s2.0-85137104249