Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F23%3A00014466" target="_blank" >RIV/75010330:_____/23:00014466 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21240/23:00369059 RIV/00216224:14110/23:00133457 RIV/00216208:11310/23:10468458
Result on the web
<a href="https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.38.2200938" target="_blank" >https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.38.2200938</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2807/1560-7917.ES.2023.28.38.2200938" target="_blank" >10.2807/1560-7917.ES.2023.28.38.2200938</a>
Alternative languages
Result language
angličtina
Original language name
Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022
Original language description
Background: The sensitivity and specificity of selected antigen detection rapid diagnostic tests (AG-RDTs) for SARS-CoV-2 were determined in the unvaccinated population when the Delta variant was circulating. Viral loads, dynamics, symptoms and tissue tropism differ between Omicron and Delta. Aim: We aimed to compare AG-RDT sensitivity and specificity in selected subgroups during Omicron vs Delta circulation. Methods: We retrospectively paired AG-RDT results with PCRs registered in Czechia's Information System for Infectious Diseases from 1 to 25 December 2021 (Delta, n = 20,121) and 20 January to 24 February 2022 (Omicron, n = 47,104). Results: When confirmatory PCR was conducted on the same day as AG-RDT as a proxy for antigen testing close to peak viral load, the average sensitivity for Delta was 80.4% and for Omicron 81.4% (p < 0.05). Sensitivity in vaccinated individuals was lower for Omicron (OR = 0.94; 95% confidence interval (CI): 0.87-1.03), particularly in reinfections (OR = 0.83; 95% CI: 0.75-0.92). Saliva AG-RDT sensitivity was below average for both Delta (74.4%) and Omicron (78.4%). Tests on the European Union Category A list had higher sensitivity than tests in Category B. The highest sensitivity for Omicron (88.5%) was recorded for patients with loss of smell or taste, however, these symptoms were almost 10-fold less common than for Delta. The sensitivity of AG-RDTs performed on initially asymptomatic individuals done 1, 2 or 3 days before a positive PCR test was consistently lower for Omicron compared with Delta. Conclusion: Sensitivity for Omicron was lower in subgroups that may become more common if SARS-CoV-2 becomes an endemic virus.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Euro Surveillance
ISSN
1025-496X
e-ISSN
1560-7917
Volume of the periodical
28
Issue of the periodical within the volume
38
Country of publishing house
SE - SWEDEN
Number of pages
14
Pages from-to
2200938
UT code for WoS article
001198382000001
EID of the result in the Scopus database
2-s2.0-85171808891