Chronic fluoride exposure and the risk of autism spectrum disorder

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75081431%3A_____%2F19%3A00001654" target="_blank" >RIV/75081431:_____/19:00001654 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1660-4601/16/18/3431" target="_blank" >https://www.mdpi.com/1660-4601/16/18/3431</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijerph16183431" target="_blank" >10.3390/ijerph16183431</a>

Result language
angličtina
Original language name
Chronic fluoride exposure and the risk of autism spectrum disorder
Original language description
The continuous rise of autism spectrum disorder (ASD) prevalent in the past few decades is causing an increase in public health and socioeconomic concern. A consensus suggests the involvement of both genetic and environmental factors in the ASD etiopathogenesis. Fluoride (F) is rarely recognized among the environmental risk factors of ASD, since the neurotoxic effects of F are not generally accepted. Our review aims to provide evidence of F neurotoxicity. We assess the risk of chronic F exposure in the ASD etiopathology and investigate the role of metabolic and mitochondrial dysfunction, oxidative stress and inflammation, immunoexcitotoxicity, and decreased melatonin levels. These symptoms have been observed both after chronic F exposure as well as in ASD. Moreover, we show that F in synergistic interactions with aluminum’s free metal cation (Al3+) can reinforce the pathological symptoms of ASD. This reinforcement takes place at concentrations several times lower than when acting alone. A high ASD prevalence has been reported from countries with water fluoridation as well as from endemic fluorosis areas. We suggest focusing the ASD prevention on the reduction of the F and Al3+ burdens from daily life.
Czech name
—
Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
—
OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical
International Journal of Environmental Research and Public Health
ISSN
1661-7827
e-ISSN
1660-4601
Volume of the periodical
16
Issue of the periodical within the volume
18
Country of publishing house
CH - SWITZERLAND
Number of pages
21
Pages from-to
1-21
UT code for WoS article
000489178500205
EID of the result in the Scopus database
2-s2.0-85072280625

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