Paradoxes of fluoride toxicity

Result code in IS VaVaI
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Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Paradoxes of fluoride toxicity
Original language description
Numerous literature sources reveal evidence that fluoride affects the activities of numerous enzymes in vitro as well as in vivo. Millions of people live in endemic fluoride areas with a severe public health problem. A plethora of data suggest that fluoride should be recognized as a developmental neurotoxicant for humans. The use of water fluoridation for the prevention of dental caries has increased the concern about adverse fluoride effects. The fluoride concentration at which a reduction in dental caries is expected is close to the level which might cause chronic pathological effects. We comment on how some of the conclusions of the recent review by Guth et al., published in Archives of Toxicology, are the emerging paradoxes in fluoride research. We show that fluoride has pluripotent effects, which might contribute to unexpected epidemics in the future.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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