Succinobucol induces apoptosis in vascular smooth muscle cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F12%3A00379061" target="_blank" >RIV/86652036:_____/12:00379061 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.freeradbiomed.2011.11.029" target="_blank" >http://dx.doi.org/10.1016/j.freeradbiomed.2011.11.029</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.freeradbiomed.2011.11.029" target="_blank" >10.1016/j.freeradbiomed.2011.11.029</a>

Result language
angličtina
Original language name
Succinobucol induces apoptosis in vascular smooth muscle cells
Original language description
Probucol inhibits the proliferation of vascular smooth muscle cells in vitro and in vivo, and the drug reduces intimal hyperplasia and atherosclerosis in animals via induction of heme oxygenase-1 (HO-1). Because the succinyl ester of probucol, succinobucol, recently failed as an antiatherogenic drug in humans, we investigated its effects on smooth muscle cell proliferation. Succinobucol and probucol induced HO-1 and decreased cell proliferation in rat aortic smooth muscle cells. However, whereas inhibition of HO-1 reversed the antiproliferative effects of probucol, this was not observed with succinobucol. Instead, succinobucol but not probucol induced caspase activity and apoptosis, and it increased mitochondrial oxidation of hydroethidine to ethidium,suggestive of the participation of H2O2 and cytochrome c. Also, succinobucol but not probucol converted cytochrome c into a peroxidase in the presence of H2O2, and succinobucol-induced apoptosis was decreased in cells that lacked cytochr
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Project
<a href="/en/project/GAP301%2F10%2F1937" target="_blank" >GAP301/10/1937: Mechanisms of efficient killing of cancer stem cells</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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