The added value of single-cell gene expression profiling
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F13%3A00398940" target="_blank" >RIV/86652036:_____/13:00398940 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/bfgp/elt001" target="_blank" >http://dx.doi.org/10.1093/bfgp/elt001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/bfgp/elt001" target="_blank" >10.1093/bfgp/elt001</a>
Alternative languages
Result language
angličtina
Original language name
The added value of single-cell gene expression profiling
Original language description
Cells are the basic unit of life and they have remarkable abilities to respond individually as well as in concert to internal and external stimuli in a specific manner. Studying complex tissues and whole organs requires understanding of cell heterogeneity and responses to stimuli at the single-cell level. In this review, we discuss the potential of single-cell gene expression profiling, focusing on data analysis and biological interpretation. We exemplify several aspects of the added value of single-cell analysis by comparing the same experimental data at both single-cell and cell population level. Data normalization and handling of missing data are two important steps in data analysis that are performed differently at single-cell level compared with cell population level. Furthermore, we discuss how single-cell gene expression data can be viewed and how subpopulations of cells can be identified and characterized.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Briefings in Functional Genomics
ISSN
2041-2649
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
81-89
UT code for WoS article
000316958500003
EID of the result in the Scopus database
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