The effect of tetrabromobisphenol A on protamine content and DNA integrity in mouse spermatozoa

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F14%3A00434224" target="_blank" >RIV/86652036:_____/14:00434224 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.2047-2927.2014.00257.x" target="_blank" >http://dx.doi.org/10.1111/j.2047-2927.2014.00257.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.2047-2927.2014.00257.x" target="_blank" >10.1111/j.2047-2927.2014.00257.x</a>

Result language
angličtina
Original language name
The effect of tetrabromobisphenol A on protamine content and DNA integrity in mouse spermatozoa
Original language description
Tetrabromobisphenol A (TBBPA) is a widely used brominated flame retardant of increasing concern to human health because of its action as an endocrine disruptor. We have previously demonstrated that TBBPA is able to increase apoptosis of testicular cellsand other changes in the first and second generations of mice exposed to TBBPA. However, the potential effects of TBBPA on mouse epididymal spermatozoa have not yet been investigated. Therefore, we initiated this study to determine whether TBBPA exposurecould also result in increased DNA fragmentation in epididymal spermatozoa and whether it had an effect on the protamines as the major nuclear proteins. C57Bl/6J mouse pups (n = 10) were exposed to TBBPA (experimental group) during the gestation, lactation, pre-pubertal and pubertal periods up to the age of 70 days as previously described and compared to control mouse pups (n = 10) that were not exposed. The results demonstrate that TBBPA treatment results in a significantly decreased p
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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