Local dynamics of proteins and DNA evaluated from crystallographic B factors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F14%3A00437245" target="_blank" >RIV/86652036:_____/14:00437245 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1107/S1399004714014631" target="_blank" >http://dx.doi.org/10.1107/S1399004714014631</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1107/S1399004714014631" target="_blank" >10.1107/S1399004714014631</a>

Result language

angličtina

Original language name

Local dynamics of proteins and DNA evaluated from crystallographic B factors

Original language description

The dynamics of protein and nucleic acid structures is as important as their average static picture. The local molecular dynamics concealed in diffraction images is expressed as so-called B factors. To find out how the crystal-derived B factors representthe dynamic behaviour of atoms and residues of proteins and DNA in their complexes, the distributions of scaled B factors from a carefully curated data set of over 700 protein-DNA crystal structures were analyzed [Schneider et al. (2014), Nucleic AcidsRes. 42, 3381-3394].Amino acids and nucleotides were categorized based on their molecular neighbourhood as solvent-accessible, solvent-inaccessible (i.e. forming the protein core) or lying at protein-protein or protein-DNA interfaces; the backbone and side-chain atoms were analyzed separately.The B factors of two types of crystal-ordered water molecules were also analyzed.The analysis confirmed several expected features of protein and DNA dynamics,but also revealed surprising facts.Solve

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Crystallographica Section D-Biological Crystallography

ISSN

0907-4449

e-ISSN

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Volume of the periodical

70

Issue of the periodical within the volume

9

Country of publishing house

DK - DENMARK

Number of pages

7

Pages from-to

2413-2419

UT code for WoS article

000341819500016

EID of the result in the Scopus database

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