Mitochondria in Cancer: Why Mitochondria Are a Good Target for Cancer Therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F14%3A00444484" target="_blank" >RIV/86652036:_____/14:00444484 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/B978-0-12-394625-6.00008-8" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-394625-6.00008-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-394625-6.00008-8" target="_blank" >10.1016/B978-0-12-394625-6.00008-8</a>

Result language
angličtina
Original language name
Mitochondria in Cancer: Why Mitochondria Are a Good Target for Cancer Therapy
Original language description
Cancer can be characterized as a state of multifaceted cellular deregulation including control of proliferation and bioenergetics. The latter involves in particular mitochondria, the site of the generation of ATP, essential for the proper cellular function (including proliferation). Mitochondria also contain a variety of proteins that are necessary for the induction/promotion, as well as for the prevention of cell death. Therefore, mitochondria are pivotal in deciding the fate of a cell. In cancer, mitochondria are dysfunctional, which was observed as early as in the 1930s by Otto Warburg. Due to the central role of mitochondria, these organelles, endowed with its own DNA, are a focus of research as possible "culprits" for the malignancy of cancer cells (or at least contributing to this phenotype) and, importantly, as emerging targets for anticancer therapy.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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