Selenium supplementation induces mitochondrial biogenesis in trophoblasts

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F15%3A00450924" target="_blank" >RIV/86652036:_____/15:00450924 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.placenta.2015.06.010" target="_blank" >http://dx.doi.org/10.1016/j.placenta.2015.06.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.placenta.2015.06.010" target="_blank" >10.1016/j.placenta.2015.06.010</a>

Result language
angličtina
Original language name
Selenium supplementation induces mitochondrial biogenesis in trophoblasts
Original language description
Introduction: Placental oxidative stress has been implicated in pregnancy complications and previous work has shown that selenium can protect trophoblast mitochondria from oxidative stress. This report examines mitochondrial function and content in trophoblasts supplemented with selenium. Methods: Swan-71, JEG-3 and BeWo cells and placental tissue were incubated with sodium selenite or selenomethionine. Mitochondrial function was examined in a respirometer. Mitochondrial content was determined using RT-PCR. The levels of the mitochondrial biogenesis markers selenoprotein H, PGC-l alpha and NRF-1 was examined by western blotting. Results: Mitochondrial respiration was significantly enhanced post selenium supplementation in cells and tissues. Selenium supplementation increased mitochondrial content and up-regulated mitochondrial biogenesis mediators in cells.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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