Gene expression profiling of changes induced by maternal diabetes in the embryonic heart

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F15%3A00453296" target="_blank" >RIV/86652036:_____/15:00453296 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.reprotox.2015.06.045" target="_blank" >http://dx.doi.org/10.1016/j.reprotox.2015.06.045</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.reprotox.2015.06.045" target="_blank" >10.1016/j.reprotox.2015.06.045</a>

Result language

angličtina

Original language name

Gene expression profiling of changes induced by maternal diabetes in the embryonic heart

Original language description

Cardiovascular defects are one of the most common congenital defects associated with maternal diabetes. Based on whole embryo gene expression microarray analysis, 11 genes were chosen for temporal expression analysis of diabetes-exposed hearts. The majority of the selected genes were deregulated in diabetes-exposed hearts compared to our controls at E13.5, E14.5, and E18.5. We showed increased hypoxia and HIF-1 alpha protein levels in diabetes-exposed hearts at E10.5, which is a critical time point forthe induction of developmental defects associated with diabetic embryopathy. Additionally, we found increased cardiac Vegfa levels that might trigger developmental abnormalities associated with diabetic embryopathy. Our results show that maternal diabetes affects the temporal expression pattern of gene encoding molecules involved in heart development and tissue remodelling and that these molecules might affect heart maturation processes and thus, the final outcome of diabetic pregnancies

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Reproductive Toxicology

ISSN

0890-6238

e-ISSN

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Volume of the periodical

57

Issue of the periodical within the volume

NOV 2015

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

147-156

UT code for WoS article

000360322300017

EID of the result in the Scopus database

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