Mitochondria: An intriguing target for killing tumour-initiating cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F16%3A00459271" target="_blank" >RIV/86652036:_____/16:00459271 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.mito.2015.12.007" target="_blank" >http://dx.doi.org/10.1016/j.mito.2015.12.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mito.2015.12.007" target="_blank" >10.1016/j.mito.2015.12.007</a>
Alternative languages
Result language
angličtina
Original language name
Mitochondria: An intriguing target for killing tumour-initiating cells
Original language description
Tumour-initiating cells (TICs) play a pivotal role in cancer initiation, metastasis and recurrence, as well as in resistance to therapy. Therefore, development of drugs targeting TICs has become a focus of contemporary research. Mitochondria have emerged as a promising target of anti-cancer therapies due to their specific role in cancer metabolism and modulation of apoptotic pathways. Mitochondria of TICs possess special characteristics, some of which can be utilised to design drugs specifically targeting these cells. In this paper, we will review recent research on TICs and their mitochondria, and introduce drugs that kill these cells by way of mitochondrial targeting. (C) 2015 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0109" target="_blank" >ED1.1.00/02.0109: Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mitochondrion
ISSN
1567-7249
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
JAN 2016
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
86-93
UT code for WoS article
000370768100010
EID of the result in the Scopus database
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