The role of nitric oxide during embryonic epidermis development of Xenopus laevis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F17%3A00482593" target="_blank" >RIV/86652036:_____/17:00482593 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/17:10360730
Result on the web
<a href="http://dx.doi.org/10.1242/bio.023739" target="_blank" >http://dx.doi.org/10.1242/bio.023739</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/bio.023739" target="_blank" >10.1242/bio.023739</a>
Alternative languages
Result language
angličtina
Original language name
The role of nitric oxide during embryonic epidermis development of Xenopus laevis
Original language description
Nitric oxide (NO) is a potent radical molecule that participates in various biological processes such as vasodilation, cell proliferation, immune response and neurotransmission. NO mainly activates soluble guanylate cyclase, leading to cGMP production and activation of protein kinase G and its downstream targets. Here we report the essential role of NO during embryonic epidermis development. Xenopus embryonic epidermis has become a useful model reflecting human epithelial tissue composition. The developing epidermis of Xenopus laevis is formed from specialized ionocytes, multi-ciliated, goblet and small secretory cells. We found that NO is mainly produced in multi-ciliated cells and ionocytes. Production of NO during early developmental stages is required for formation of multi-ciliated cells, ionocytes and small secretory cells by regulation of epidermal-specific gene expression. The data from this research indicate a novel role of NO during development, which supports recent findings of NO production in human mucociliary and epithelium development.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biology Open
ISSN
2046-6390
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
862-871
UT code for WoS article
000403449400015
EID of the result in the Scopus database
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