The mobility of mitochondria: Intercellular trafficking in health and disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F17%3A00507981" target="_blank" >RIV/86652036:_____/17:00507981 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/1440-1681.12764" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/1440-1681.12764</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/1440-1681.12764" target="_blank" >10.1111/1440-1681.12764</a>
Alternative languages
Result language
angličtina
Original language name
The mobility of mitochondria: Intercellular trafficking in health and disease
Original language description
The view that genes are constrained within somatic cells is challenged by in vitro evidence, and more recently by in vivo studies which demonstrate that mitochondria with their mitochondrial DNA (mtDNA) payload not only can, but do move between cells in tumour models and in mouse models of tissue damage. Using mouse tumour cell models without mtDNA to reflect mtDNA damage, we have shown that these cells grow tumours only after acquiring mtDNA from cells in the local microenvironment resulting in respiration recovery, tumorigenesis and metastasis. Mitochondrial transfer between cells has also been demonstrated following ischaemia-induced injury in the heart and brain and in lung epithelium, and following lung inflammation. In vitro investigations suggest that stem cells may be mitochondrial donors. The ability of mitochondria to move between cells appears to be an evolutionarily-conserved phenomenon, relevant to diseases with compromised mitochondrial function including neurodegenerative, neuromuscular and cardiovascular diseases as well as cancer and ageing.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical and Experimental Pharmacology and Physiology
ISSN
1440-1681
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
DEC 2017
Country of publishing house
AU - AUSTRALIA
Number of pages
6
Pages from-to
15-20
UT code for WoS article
000418663800003
EID of the result in the Scopus database
2-s2.0-85030033108