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Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F19%3A00521329" target="_blank" >RIV/86652036:_____/19:00521329 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/19:10395615 RIV/00216208:11130/19:10395615 RIV/61384399:31140/19:00053787 RIV/00064203:_____/19:10395615 and 2 more

  • Result on the web

    <a href="https://clincancerres.aacrjournals.org/content/25/14/4455" target="_blank" >https://clincancerres.aacrjournals.org/content/25/14/4455</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1158/1078-0432.CCR-18-3275" target="_blank" >10.1158/1078-0432.CCR-18-3275</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma

  • Original language description

    Purpose: Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell non-Hodgkin lymphomas characterized by (over) expression of BCL2. A BCL2-targeting drug, venetoclax, has promising anticancer activity in MCL. We analyzed molecular mechanisms of venetoclax resistance in MCL cells and tested strategies to overcome it.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

    <a href="/en/project/NV17-28980A" target="_blank" >NV17-28980A: New prognostic and predictive markers in patients with mantle cell lymphoma at diagnosis and on treatment</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Cancer Research

  • ISSN

    1078-0432

  • e-ISSN

  • Volume of the periodical

    25

  • Issue of the periodical within the volume

    14

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    4455-4465

  • UT code for WoS article

    000478018100027

  • EID of the result in the Scopus database