Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F20%3A00525375" target="_blank" >RIV/86652036:_____/20:00525375 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/20:10414843
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0925443920301046?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0925443920301046?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbadis.2020.165759" target="_blank" >10.1016/j.bbadis.2020.165759</a>

Result language
angličtina
Original language name
Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer
Original language description
Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. In mammalian cells, DHODH is localized in mitochondria, linked to the respiratory chain via the coenzyme Q pool. Here we discuss the role of DHODH in the oxidative phosphorylation system and in the initiation and progression of cancer. We summarize recent findings on DHODH biology, the progress made in the development of new, specific inhibitors of DHODH intended for cancer therapy, and the mechanistic insights into the consequences of DHODH inhibition.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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