Mitochondrial complex II and reactive oxygen species in disease and therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F20%3A00535930" target="_blank" >RIV/86652036:_____/20:00535930 - isvavai.cz</a>
Result on the web
<a href="https://www.tandfonline.com/doi/pdf/10.1080/13510002.2020.1752002?needAccess=true&" target="_blank" >https://www.tandfonline.com/doi/pdf/10.1080/13510002.2020.1752002?needAccess=true&</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/13510002.2020.1752002" target="_blank" >10.1080/13510002.2020.1752002</a>

Result language
angličtina
Original language name
Mitochondrial complex II and reactive oxygen species in disease and therapy
Original language description
Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact on the development of pathophysiological conditions, i.e. cancer and neurodegenerative diseases. While the basic framework of CII involvement in ROS production has been defined, the fine details still await clarification. It is important to resolve these aspects to fully understand the role of CII in pathology and to explore its therapeutic potential in cancer and other diseases.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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