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Porcine model for the study of sperm capacitation, fertilization and male fertility

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F20%3A00541337" target="_blank" >RIV/86652036:_____/20:00541337 - isvavai.cz</a>

  • Alternative codes found

    RIV/60460709:41210/20:81704

  • Result on the web

    <a href="https://link.springer.com/article/10.1007%2Fs00441-020-03181-1" target="_blank" >https://link.springer.com/article/10.1007%2Fs00441-020-03181-1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00441-020-03181-1" target="_blank" >10.1007/s00441-020-03181-1</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Porcine model for the study of sperm capacitation, fertilization and male fertility

  • Original language description

    Mammalian fertilization remains a poorly understood event with the vast majority of studies done in the mouse model. The purpose of this review is to revise the current knowledge about semen deposition, sperm transport, sperm capacitation, gamete interactions and early embryonic development with a focus on the porcine model as a relevant, alternative model organism to humans. The review provides a thorough overview of post-ejaculation events inside the sow's reproductive tract including comparisons with humans and implications for human fertilization and assisted reproductive therapy (ART). Porcine methodology for sperm handling, preservation, in vitro capacitation, oocyte in vitro maturation, in vitro fertilization and intra-cytoplasmic sperm injection that are routinely used in pig research laboratories can be successfully translated into ART to treat human infertility. Last, but not least, new knowledge about mitochondrial inheritance in the pig can provide an insight into human mitochondrial diseases and new knowledge on polyspermy defense mechanisms could contribute to the development of new male contraceptives.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cell and Tissue Research

  • ISSN

    0302-766X

  • e-ISSN

  • Volume of the periodical

    380

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    6

  • Pages from-to

    237-262

  • UT code for WoS article

    000531154800004

  • EID of the result in the Scopus database

    2-s2.0-85081633316