Porcine model for the study of sperm capacitation, fertilization and male fertility
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F20%3A00541337" target="_blank" >RIV/86652036:_____/20:00541337 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41210/20:81704
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00441-020-03181-1" target="_blank" >https://link.springer.com/article/10.1007%2Fs00441-020-03181-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00441-020-03181-1" target="_blank" >10.1007/s00441-020-03181-1</a>
Alternative languages
Result language
angličtina
Original language name
Porcine model for the study of sperm capacitation, fertilization and male fertility
Original language description
Mammalian fertilization remains a poorly understood event with the vast majority of studies done in the mouse model. The purpose of this review is to revise the current knowledge about semen deposition, sperm transport, sperm capacitation, gamete interactions and early embryonic development with a focus on the porcine model as a relevant, alternative model organism to humans. The review provides a thorough overview of post-ejaculation events inside the sow's reproductive tract including comparisons with humans and implications for human fertilization and assisted reproductive therapy (ART). Porcine methodology for sperm handling, preservation, in vitro capacitation, oocyte in vitro maturation, in vitro fertilization and intra-cytoplasmic sperm injection that are routinely used in pig research laboratories can be successfully translated into ART to treat human infertility. Last, but not least, new knowledge about mitochondrial inheritance in the pig can provide an insight into human mitochondrial diseases and new knowledge on polyspermy defense mechanisms could contribute to the development of new male contraceptives.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell and Tissue Research
ISSN
0302-766X
e-ISSN
—
Volume of the periodical
380
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
237-262
UT code for WoS article
000531154800004
EID of the result in the Scopus database
2-s2.0-85081633316