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Ligands and Receptors Involved in the Sperm-Zona Pellucida Interactions in Mammals

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F21%3A00540510" target="_blank" >RIV/86652036:_____/21:00540510 - isvavai.cz</a>

  • Alternative codes found

    RIV/60460709:41210/21:88415

  • Result on the web

    <a href="https://www.mdpi.com/2073-4409/10/1/133" target="_blank" >https://www.mdpi.com/2073-4409/10/1/133</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/cells10010133" target="_blank" >10.3390/cells10010133</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Ligands and Receptors Involved in the Sperm-Zona Pellucida Interactions in Mammals

  • Original language description

    Sperm-zona pellucida (ZP) interaction, involving the binding of sperm surface ligands to complementary carbohydrates of ZP, is the first direct gamete contact event crucial for subsequent gamete fusion and successful fertilization in mammals. It is a complex process mediated by the coordinated engagement of multiple ZP receptors forming high-molecular-weight (HMW) protein complexes at the acrosomal region of the sperm surface. The present article aims to review the current understanding of sperm-ZP binding in the four most studied mammalian models, i.e., murine, porcine, bovine, and human, and summarizes the candidate ZP receptors with established ZP affinity, including their origins and the mechanisms of ZP binding. Further, it compares and contrasts the ZP structure and carbohydrate composition in the aforementioned model organisms. The comprehensive understanding of sperm-ZP interaction mechanisms is critical for the diagnosis of infertility and thus becomes an integral part of assisted reproductive therapies/technologies.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cells

  • ISSN

    2073-4409

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    36

  • Pages from-to

    133

  • UT code for WoS article

    000609970000001

  • EID of the result in the Scopus database

    2-s2.0-85100117939