Ligands and Receptors Involved in the Sperm-Zona Pellucida Interactions in Mammals

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F21%3A00540510" target="_blank" >RIV/86652036:_____/21:00540510 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41210/21:88415

Result on the web

<a href="https://www.mdpi.com/2073-4409/10/1/133" target="_blank" >https://www.mdpi.com/2073-4409/10/1/133</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cells10010133" target="_blank" >10.3390/cells10010133</a>

Result language

angličtina

Original language name

Ligands and Receptors Involved in the Sperm-Zona Pellucida Interactions in Mammals

Original language description

Sperm-zona pellucida (ZP) interaction, involving the binding of sperm surface ligands to complementary carbohydrates of ZP, is the first direct gamete contact event crucial for subsequent gamete fusion and successful fertilization in mammals. It is a complex process mediated by the coordinated engagement of multiple ZP receptors forming high-molecular-weight (HMW) protein complexes at the acrosomal region of the sperm surface. The present article aims to review the current understanding of sperm-ZP binding in the four most studied mammalian models, i.e., murine, porcine, bovine, and human, and summarizes the candidate ZP receptors with established ZP affinity, including their origins and the mechanisms of ZP binding. Further, it compares and contrasts the ZP structure and carbohydrate composition in the aforementioned model organisms. The comprehensive understanding of sperm-ZP interaction mechanisms is critical for the diagnosis of infertility and thus becomes an integral part of assisted reproductive therapies/technologies.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cells

ISSN

2073-4409

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

36

Pages from-to

133

UT code for WoS article

000609970000001

EID of the result in the Scopus database

2-s2.0-85100117939